帽柱木生物碱提取物对大鼠食物和水摄入量及体重的急性和长期影响
Acute and long-term effects of alkaloid extract of Mitragyna speciosa on food and water intake and body weight in rats.
作者信息
Kumarnsit Ekkasit, Keawpradub Niwat, Nuankaew Watcharin
机构信息
Department of Physiology, Faculty of Science, Prince of Songkla University (PSU), Hat-Yai, Songkhla 90112, Thailand.
出版信息
Fitoterapia. 2006 Jul;77(5):339-45. doi: 10.1016/j.fitote.2006.04.006. Epub 2006 Apr 30.
PMID:16781828
Abstract
Acute administration of Mitragyna speciosa (MS) extract (45 and 50 mg/kg) significantly resulted in dose-dependent decreases in food and water intakes (P<0.05) in rats. Prolonged suppressing effects were observed following administration of the MS extract (40 mg/kg) for 60 consecutive days. Moreover, the long-term administration also significantly suppressed weight gaining.
摘要
急性给予帽柱木提取物（45和50毫克/千克）显著导致大鼠的食物和水摄入量呈剂量依赖性减少（P<0.05）。连续60天给予帽柱木提取物（40毫克/千克）后观察到持续的抑制作用。此外，长期给药也显著抑制体重增加。
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