Buusman Allan, Kragstrup Jakob, Andersen Morten
Research Unit for General Practice, University of Southern Denmark, J.B. Winsløws Vej 9 A, 5000, Odense C, Denmark.
Eur J Clin Pharmacol. 2006 Jul;62(7):577-83. doi: 10.1007/s00228-006-0126-y. Epub 2006 Jun 17.
The aims of this study were to analyse (1) if it is possible to classify general practitioners (GPs) or groups of practitioners (practice units) as overall narrow or wide prescribers and (2) to what extent the size of practice drug formularies is associated with general prescribing behaviour, practice activity and demography.
Data were retrieved from the Odense University Pharmacoepidemiologic Database (OPED) and the prescribing patterns of 177 practice units were analysed in a 4-year period including 2000 and 2003. We characterised the drug repertoire for new treatments using a Formulary Diversity Scale based on two formulary measures, the DU 90% and the Formulary Selectivity Index. Multiple regressions were used to analyse the association between formulary size and practice characteristics.
The final Formulary Diversity Scale comprised 15 therapeutic drug groups and 151 different analogues. The average score based on the DU 90% segment was 46 drugs (range: 28-65) corresponding to 30% of drugs available. Using the Formulary Selectivity Index the average diversity score was 0.70. Practices with a high number of patients and a high percentage of elderly patients were more likely to use a wide range of drugs.
The Formulary Diversity Scale revealed wide variation between practice units, indicating the existence of both overall narrow and wide prescribers among GPs. The number of patients attending the practice and the percentage of elderly patients were directly associated with the use of more analogues.
本研究旨在分析(1)是否有可能将全科医生(GPs)或医生群体(执业单位)分类为总体用药范围窄或宽的处方者,以及(2)执业药物处方集的规模在多大程度上与总体处方行为、执业活动和人口统计学相关。
数据取自欧登塞大学药物流行病学数据库(OPED),并在包括2000年和2003年的4年期间分析了177个执业单位的处方模式。我们使用基于两种处方集度量(DU 90%和处方集选择性指数)的处方集多样性量表来描述新治疗药物的种类。采用多元回归分析处方集规模与执业特征之间的关联。
最终的处方集多样性量表包括15个治疗药物组和151种不同的类似物。基于DU 90%部分的平均分数为46种药物(范围:28 - 65种),相当于可用药物的30%。使用处方集选择性指数,平均多样性分数为0.70。患者数量多且老年患者比例高的执业单位更有可能使用广泛的药物。
处方集多样性量表显示执业单位之间存在很大差异,表明全科医生中既有总体用药范围窄的处方者,也有总体用药范围宽的处方者。就诊患者数量和老年患者比例与更多类似物的使用直接相关。