来自郎氏肉豆蔻的对映-蛇麻烷二萜类化合物。

ent-Trachylobane diterpenoids from Xylopia langsdorffiana.

作者信息

Tavares Josean Fechine, Queiroga Karine F, Silva Marianna Vieira B, Diniz Margareth F F M, Filho José M B, da-Cunha Emidio V L, de Simone Carlos Alberto, Júnior João X de Araújo, Melo Patrícia S, Haun Marcela, da Silva Marcelo Sobral

机构信息

Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Cx. Postal 5009, 58051-970, João Pessoa, Paraíba, Brazil.

出版信息

J Nat Prod. 2006 Jun;69(6):960-2. doi: 10.1021/np050503o.

DOI:10.1021/np050503o

PMID:16792419

Abstract

Two new diterpenes of the ent-trachylobane type were isolated from the stems of Xylopia langsdorffiana, ent-7alpha-acetoxytrachyloban-18-oic acid (1) and ent-7alpha-hydroxytrachyloban-18-oic acid (2). The structures of these isolates were deduced by spectroscopic data interpretation. X-ray crystallography of 1 was used to confirm its structure. The cytotoxic activity of 1 against V79 fibroblasts and rat hepatocytes was investigated.

摘要

从郎氏木瓣树的茎中分离出两种新的对映-环阿尔廷烷型二萜，对映-7α-乙酰氧基环阿尔廷烷-18-酸（1）和对映-7α-羟基环阿尔廷烷-18-酸（2）。通过光谱数据解析推导了这些分离物的结构。利用1的X射线晶体学确定其结构。研究了1对V79成纤维细胞和大鼠肝细胞的细胞毒性活性。