Scripture Charity D, Figg William D
Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, MSC1910, Bethesda, Maryland 20892, USA.
Nat Rev Cancer. 2006 Jul;6(7):546-58. doi: 10.1038/nrc1887.
Drug interactions in oncology are of particular importance owing to the narrow therapeutic index and the inherent toxicity of anticancer agents. Interactions with other medications can cause small changes in the pharmacokinetics or pharmacodynamics of a chemotherapy agent that could significantly alter its efficacy or toxicity. Improvements in in vitro methods and early clinical testing have made the prediction of potentially clinically significant drug interactions possible. We outline the types of drug interaction that occur in oncology, the mechanisms that underlie these interactions and describe select examples.
由于抗癌药物的治疗指数狭窄以及固有的毒性，肿瘤学中的药物相互作用尤为重要。与其他药物的相互作用可导致化疗药物的药代动力学或药效学发生微小变化，进而可能显著改变其疗效或毒性。体外方法和早期临床试验的改进使得预测潜在的具有临床意义的药物相互作用成为可能。我们概述了肿瘤学中发生的药物相互作用类型、这些相互作用的潜在机制，并描述了一些实例。
