Werner William G, DiFrancisco-Donoghue Joanne, Lamberg Eric M
Department of Physical Therapy, School of Health Professions, Behavioral and Life Science, New York Institute of Technology, Old Westbury, NY, USA.
J Neurol Phys Ther. 2006 Jun;30(2):68-73. doi: 10.1097/01.npt.0000282570.78544.00.
Exercise has been recommended as a way to maintain quality of life in individuals with Parkinson disease (PD). Experiments examining the cardiovascular response to exercise, however, have yielded controversial results. This study was designed to determine if there is any difference in vital signs and Rate of Perceived Exertion (RPE) between a group of individuals (50-80 years old) with PD and a comparison group of healthy individuals during exercise on a treadmill.
Twenty seven volunteers (16 with PD and 11 healthy) participated in this study. Subjects with PD were divided into 2 groups; one that reached target heart rate and one that failed to reach it. In this study, heart rate (HR), systolic blood pressure (BP), and the RPE were measured during a Modified Bruce Protocol. We hypothesized that treadmill testing would result in differences between individuals with PD and healthy subjects when HR and systolic BP were compared at submaximal exercise (defined as Stage 2 of the Modified Bruce Protocol) and at peak exercise (defined as 85% of age predicted target heart rate).
During submaximal exercise, no significant differences were found between the PD group and the control group for HR, BP, or RPE. At peak exercise, one half of the subjects with PD exhibited blunted cardiovascular responses, despite reaching a comparable intensity of exercise during a Modified Bruce Protocol.
Although cardiovascular responses to exercise on a treadmill appear similar between individuals with PD and controls at lower levels of exercise, half the subjects with PD in the present study displayed abnormal cardiovascular responses at higher exercise intensities. Administering an exercise stress test will illustrate the expected cardiovascular responses for each individual, therefore guiding exercise prescription.
运动已被推荐为维持帕金森病（PD）患者生活质量的一种方式。然而，研究运动时心血管反应的实验得出了相互矛盾的结果。本研究旨在确定一组50至80岁的PD患者与健康对照组在跑步机上运动时，生命体征和主观用力程度分级（RPE）是否存在差异。
27名志愿者（16名PD患者和11名健康者）参与了本研究。PD患者被分为两组，一组达到目标心率，另一组未达到目标心率。在本研究中，在改良布鲁斯运动试验过程中测量心率（HR）、收缩压（BP）和RPE。我们假设，在次极量运动（定义为改良布鲁斯运动试验的第2阶段）和峰值运动（定义为年龄预测目标心率的85%）时比较HR和收缩压，跑步机测试会导致PD患者和健康受试者之间存在差异。
在次极量运动期间，PD组和对照组在HR、BP或RPE方面未发现显著差异。在峰值运动时，尽管在改良布鲁斯运动试验中达到了相当的运动强度，但一半的PD患者表现出心血管反应迟钝。
尽管在较低运动水平时，PD患者和对照组在跑步机上运动时的心血管反应似乎相似，但本研究中一半的PD患者在较高运动强度时表现出异常的心血管反应。进行运动应激试验将阐明每个个体预期的心血管反应，从而指导运动处方。
