Sarkar Purnima Dey, T M Shivaprakash, Madhusudhan Basavaraj
Department of Biochemistry, M.G.M. Medical College, Indore 452 001, M.P., India.
Clin Chim Acta. 2006 Nov;373(1-2):77-81. doi: 10.1016/j.cca.2006.05.005. Epub 2006 May 11.
South Asians, especially Indians show increased risk for atherosclerosis and have the higher mortality rates due to coronary artery disease. The increasing incidence of coronary artery disease in young patients is possibly due to industrialization, stress of life, less exercise and increasing incidence of smoking and other factors. We attempted to determine an independent association of paraoxonase with coronary artery disease in young patients.
The lipid profile and serum paraoxonase were investigated in 120 angiographically-proven premature coronary artery disease patients (99 males and 21 females, all <45 years) with diabetes mellitus, smoking, hyperlipidemia, obesity, hypertension along with 50 (41 male and 9 female) normal subjects and compared.
A significant increase was observed in the concentrations of total cholesterol, triglycerides and LDL cholesterol in premature coronary artery disease patients. The activities of paraoxonase and HDL cholesterol concentrations decreased in coronary artery disease patients compared to control subjects.
A paraoxonase was an independent (p<0.001, OR 14.9 and 95% CI 5.6-35.9) risk factor for premature coronary artery disease patients along with lipid profiles. Paraoxonase activity should be evaluated in all coronary artery disease patients in the absence of traditional risk factors.
南亚人，尤其是印度人，动脉粥样硬化风险增加，且因冠状动脉疾病导致的死亡率更高。年轻患者中冠状动脉疾病发病率不断上升，可能归因于工业化、生活压力、运动量减少、吸烟率上升及其他因素。我们试图确定对氧磷酶与年轻患者冠状动脉疾病之间的独立关联。
对120例经血管造影证实的患有糖尿病、吸烟、高脂血症、肥胖症、高血压的早发冠状动脉疾病患者（99例男性和21例女性，均<45岁）以及50例（41例男性和9例女性）正常受试者的血脂谱和血清对氧磷酶进行了研究并比较。
早发冠状动脉疾病患者的总胆固醇、甘油三酯和低密度脂蛋白胆固醇浓度显著升高。与对照组相比，冠状动脉疾病患者的对氧磷酶活性和高密度脂蛋白胆固醇浓度降低。
对氧磷酶是早发冠状动脉疾病患者的一个独立（p<0.001，OR 14.9，95%CI 5.6 - 35.9）危险因素，与血脂谱一样。在没有传统危险因素的所有冠状动脉疾病患者中都应评估对氧磷酶活性。
