Bhattacharyya T K, Calas A, Assenmacher I
Cell Tissue Res. 1975 Jul 8;160(2):219-29. doi: 10.1007/BF00220579.
The functional zonation in the adrenocortical tissue of the duck was experimentally investigated after chronic administration of corticosteroids of different types (corticosterone, desoxycorticosterone, dexamethasone) and salt loading (chlorides of sodium and potassium). The cytomorphology of the interrenal cells belonging to subcapsular and central zones was explored by light- and electron microscopy and by biochemical analysis of plasma corticosterone. Corticoid-induced involution of the interrenal tissue, or hyperactivity elicited by salt loading were evident in both subcapsular and central regions of the gland. In the duck the adrenocortical tissue appears to be devoid of steroidogenic functional differentiation. The modifications of different cellular organelles and inclusions can be explained in the light of known concepts about corticosteroid metabolism. The depression of plasma corticosterone titre in corticosteroid-treated animals agrees with the image of cytological inhibition. The lowered corticosterone value in KCl-loaded ducks signifies increased peripheral metabolism of this hormone. The hypercorticosteronemia in NaCl-loaded ducks is probably related to activation of the nasal gland under osmotic stress.
在长期给予不同类型的皮质类固醇（皮质酮、脱氧皮质酮、地塞米松）以及盐负荷（氯化钠和氯化钾）后，对鸭肾上腺皮质组织的功能分区进行了实验研究。通过光学显微镜和电子显微镜以及血浆皮质酮的生化分析，探究了属于被膜下区和中央区的肾上腺皮质细胞的细胞形态学。在肾上腺的被膜下区和中央区，均明显出现了皮质类固醇诱导的肾上腺皮质组织退化或盐负荷引起的肾上腺皮质组织功能亢进。在鸭中，肾上腺皮质组织似乎缺乏类固醇生成功能分化。不同细胞器和内含物的变化可以根据关于皮质类固醇代谢的已知概念来解释。皮质类固醇处理动物中血浆皮质酮水平的降低与细胞学抑制的表现相符。氯化钾负荷鸭中皮质酮值的降低表明该激素的外周代谢增加。氯化钠负荷鸭中的高皮质酮血症可能与渗透压应激下鼻腺的激活有关。
