遗传性和获得性血栓形成倾向：妊娠结局与治疗

Inherited and acquired thrombophilia: pregnancy outcome and treatment.

作者信息

De Santis Marco, Cavaliere A F, Straface G, Di Gianantonio E, Caruso A

机构信息

Telefono Rosso-Teratology Information Service, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Largo A. Gemelli, 8, 00168 Rome, Italy.

出版信息

Reprod Toxicol. 2006 Aug;22(2):227-33. doi: 10.1016/j.reprotox.2006.05.002. Epub 2006 Jun 23.

DOI:10.1016/j.reprotox.2006.05.002

PMID:16797917

Abstract

Maternal thrombophilias increases the risk of an adverse pregnancy outcome. An extensive literature review highlights the role of inherited and acquired thrombophilic disorders in spontaneous abortion, both early and late, recurrent or isolate, in intrauterine growth retardation, in placenta abruption, in pre-eclampsia and in venous thromboembolism. We have particularly focused attention on the following factors: antithrombin III (ATIII), proteins C (PC) and S (PS) deficiencies, genetic mutations particularly factor V Leiden (FVL), prothrombin gene G20210A (PTM) and the thermolabile variant of the methylene tetrahydrofolate reductase C677T (MTHFR) gene, lupus anticoagulant (LAC) and anticardiolipin antibodies, VIIIc factor, hyperhomocysteinemia and acquired activated protein C resistance. Appropriate treatment can improve pregnancy outcome without teratogenic effects.

摘要

母亲血栓形成倾向会增加不良妊娠结局的风险。一项广泛的文献综述强调了遗传性和获得性血栓形成障碍在早期和晚期、复发性或孤立性自然流产、宫内生长迟缓、胎盘早剥、先兆子痫以及静脉血栓栓塞中的作用。我们特别关注了以下因素：抗凝血酶III（ATIII）、蛋白C（PC）和蛋白S（PS）缺乏、基因突变，尤其是因子V莱顿（FVL）、凝血酶原基因G20210A（PTM）以及亚甲基四氢叶酸还原酶C677T（MTHFR）基因的不耐热变体、狼疮抗凝物（LAC）和抗心磷脂抗体、VIIIc因子、高同型半胱氨酸血症以及获得性活化蛋白C抵抗。适当的治疗可改善妊娠结局且无致畸作用。