恩瑞格（ICL 670）：一种新型口服铁螯合剂。

Exjade (ICL 670): A new oral iron chelator.

作者信息

Agarwal M B

机构信息

Department of Haematology, Bombay Hospital Institute of Medical Sciences, Marine Lines, Mumbai 400 020.

出版信息

J Assoc Physicians India. 2006 Mar;54:214-7.

PMID:16800349

Abstract

ICL670(deferasirox) is a tridentate oral iron chelator that has shown high efficacy and theraputic safety in preclinical and currently ongoing phase III clinical evaluation. The drug has been just approved by US FDA for use in iron-loading anaemias. It is an ideal once-daily oral chelator, the effective dose of which is between 20 and 40 mg/kg. Iron is chelated & excreted almost exclusively via the feces. This is a major advance in the field of iron chelation.

摘要

ICL670（地拉罗司）是一种三齿口服铁螯合剂，在临床前和目前正在进行的III期临床评估中已显示出高效性和治疗安全性。该药物刚刚获得美国食品药品监督管理局（US FDA）批准用于治疗铁过载贫血。它是一种理想的每日一次口服螯合剂，有效剂量为20至40毫克/千克。铁几乎完全通过粪便被螯合并排出。这是铁螯合领域的一项重大进展。