与组织激肽释放酶具有同源性的丝氨酸蛋白酶的综合命名法。

A comprehensive nomenclature for serine proteases with homology to tissue kallikreins.

作者信息

Lundwall Ake, Band Vimla, Blaber Michael, Clements Judith A, Courty Yves, Diamandis Eleftherios P, Fritz Hans, Lilja Hans, Malm Johan, Maltais Lois J, Olsson A Yvonne, Petraki Constantina, Scorilas Andreas, Sotiropoulou Georgia, Stenman Ulf-Håkan, Stephan Carsten, Talieri Maroulio, Yousef George M

机构信息

Lund University, Clinical Chemistry, Department of Laboratory Medicine, University Hospital MAS, S-205 02 Malmö, Sweden.

出版信息

Biol Chem. 2006 Jun;387(6):637-41. doi: 10.1515/BC.2006.082.

DOI:10.1515/BC.2006.082

PMID:16800724

Abstract

The human kallikrein locus on chromosome 19q13.3-13.4 contains kallikrein 1--the tissue kallikrein--and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present nomenclature for these proteins is inadequate or insufficient. Here we present a new nomenclature in which proteins without proven kininogenase activity are denoted kallikrein-related peptidase. Names are also given to the unique rodent proteins that are closely related to kallikrein 1.

摘要

位于19号染色体q13.3 - 13.4区域的人类激肽释放酶基因座包含激肽释放酶1（组织激肽释放酶）和14种相关丝氨酸蛋白酶。最近对它们功能和进化的研究表明，目前这些蛋白质的命名法不充分或不完善。在此，我们提出一种新的命名法，其中未被证实具有激肽原酶活性的蛋白质被命名为激肽释放酶相关肽酶。我们还为与激肽释放酶1密切相关的独特啮齿动物蛋白质命名。