Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS.

作者信息

Fernández-Santiago R, Sharma M, Mueller J C, Gohlke H, Illig T, Anneser J, Münch C, Ludolph A, Kamm C, Gasser T

机构信息

Department of Neurodegenerative Diseases, Hertie-Institute for Brain Research, Eberhard-Karls University, Tuebingen, Germany.

出版信息

Neurology. 2006 Jun 27;66(12):1929-31. doi: 10.1212/01.wnl.0000219756.71928.25.

DOI:10.1212/01.wnl.0000219756.71928.25

PMID:16801663

Abstract

Individuals homozygous for haplotypes -2578-A/-1154-A/-634-G or -2578-A/-1154-G/-634-G in the promoter/5'UTR of the VEGF gene have a 1.8-fold increased risk of ALS in several European populations. We did not observe any significant association with single markers, or haplotype pairs, in a German sample of 580 sporadic ALS patients and 628 controls. However, the promoter SNP-1154 (rs1570360) was associated with affection status in women (p = 0.036), suggesting that the VEGF effect may be dependent on the sex ratio of the sample.

摘要