CARF通过多个检查点调节p19ARF-p53-p21WAF1衰老途径。
CARF regulates p19ARF-p53-p21WAF1 senescence pathway by multiple checkpoints.
作者信息
Kaul Sunil C, Hasan Kamrul, Wadhwa Renu
机构信息
National Institute of Advanced Industrial Science & Technology (AIST), Tsukuba, Ibaraki, Japan.
出版信息
Ann N Y Acad Sci. 2006 May;1067:217-9. doi: 10.1196/annals.1354.026.
PMID:16803988
Abstract
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. We demonstrate that p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
摘要
CARF最初是通过酵母相互作用筛选作为ARF的一种新型结合伴侣被克隆出来的。CARF和ARF在核仁周围区域共定位并具有协同功能。在核质中，CARF与p53相互作用并增强其功能。我们证明p53在负反馈调节环中下调CARF，并且可能还涉及p53拮抗剂HDM2。
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