Singh Ripudaman, Kølvraa Steen, Bross Peter, Christensen Kaare, Gregersen Niels, Tan Qihua, Jensen Uffe Birk, Eiberg Hans, Rattan Suresh I S
Department of Human Genetics, Bartholin Building, University of Aarhus, Denmark.
Ann N Y Acad Sci. 2006 May;1067:301-8. doi: 10.1196/annals.1354.040.
We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat-shock protein) genes on 6p21 with human longevity. The availability of biological samples from various population cohorts in Denmark has given us the opportunity to try novel methods of gene association with human longevity. A significant association of one haplotype with male longevity was observed. Furthermore, a significant difference in the survival of the carriers of the different genotypes in females was observed. We also found an age-dependant decline in the ability of peripheral blood mononuclear cells to respond to heat stress in terms of Hsp70 induction.
我们研究了位于6号染色体短臂21区的三个热休克蛋白70（HSP70）基因中存在的三个单核苷酸多态性（SNP）与人类长寿之间的关联。丹麦不同人群队列提供的生物样本使我们有机会尝试基因与人类长寿关联的新方法。观察到一种单倍型与男性长寿存在显著关联。此外，还观察到女性不同基因型携带者的存活率存在显著差异。我们还发现，外周血单核细胞在热休克蛋白70诱导方面对热应激的反应能力随年龄增长而下降。
