A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity.

作者信息

Zhao Yongmei, He Weijiang, Shi Pengfei, Zhu Jianhui, Qiu Lin, Lin Liping, Guo Zijian

机构信息

State Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, P R China.

出版信息

Dalton Trans. 2006 Jun 14(22):2617-9. doi: 10.1039/b601739h. Epub 2006 Mar 27.

A trinuclear 3N-chelated monofunctional platinum complex, Pt3(HPTAB)Cl33 (HPTAB = N,N,N',N',N'',N''-hexakis(2-pyridylmethyl)-1,3,5-tris(aminomethyl)benzene), has been structurally characterized, which binds to DNA and demonstrates much higher potency against the murine leukemia cell line (P-388) and the human nonsmall-cell lung cancer cell line (A-549) than cisplatin.