Memiş D, Dökmeci D, Karamanlioğlu B, Turan A, Türe M
Trakya University, Department of Anaesthesiology and Reanimation, Edirne, Turkey.
Eur J Anaesthesiol. 2006 Aug;23(8):700-4. doi: 10.1017/S0265021506000512.
Propofol and dexmedetomidine are widely used for sedation in the intensive care unit yet there are limited data on its effects on gastric motility. In our preliminary study, we examined whether or not any effect of propofol and dexmedetomidine on gastric emptying is preserved in critically ill patients.
Twenty-four critically ill, enterally fed adult patients each received enteral feeding via a nasogastric tube at 50 mL h-1 throughout the 5-h study period. Either propofol 2 mg kg-1 h-1 (n = 12, Group P) or dexmedetomidine 0.2 microg kg-1 h- (n = 12, Group D) was given intravenously over 5 h. Gastric motility was measured indirectly by analysis of the absorption over time of 1.5 g of paracetamol administered into the stomach at the start of the study period. At the beginning and end of the study, residual gastric volume and pH of residual gastric fluid were measured.
Gastric residual volume measured at the end of propofol infusion (19.33 +/- 11.33) was found to be higher when compared with the volume measured before infusion (11.33 +/- 4.84) and after dexmedetomidine infusion (9.17 +/- 4.54). But, there was no difference between groups in gastric emptying time (AUC120 894.53 +/- 499.39 vs. 1113.46 +/- 598.09 propofol and dexmedetomidine groups, respectively).
In our study, gastric residual volume measured at the end of propofol infusion was found to be higher when compared with the volume measured before infusion and after dexmedetomidine infusion. There was no difference between groups in gastric emptying time.
丙泊酚和右美托咪定在重症监护病房中广泛用于镇静,但关于其对胃动力影响的数据有限。在我们的初步研究中,我们检查了丙泊酚和右美托咪定对危重症患者胃排空是否有任何影响。
24名危重症成年肠内营养患者在整个5小时的研究期间均通过鼻胃管以50 mL/h的速度接受肠内营养。在5小时内静脉给予丙泊酚2 mg·kg⁻¹·h⁻¹(n = 12,P组)或右美托咪定0.2 μg·kg⁻¹·h⁻¹(n = 12,D组)。通过分析在研究开始时注入胃内的1.5 g对乙酰氨基酚随时间的吸收情况间接测量胃动力。在研究开始和结束时,测量胃残余量和残余胃液的pH值。
发现丙泊酚输注结束时测得的胃残余量(19.33±11.33)高于输注前(11.33±4.84)和右美托咪定输注后(9.17±4.54)测得的量。但是,丙泊酚组和右美托咪定组的胃排空时间没有差异(曲线下面积分别为894.53±499.39和1113.46±598.09)。
在我们的研究中,发现丙泊酚输注结束时测得的胃残余量高于输注前和右美托咪定输注后测得的量。两组的胃排空时间没有差异。