Lebovitz R M
Epilepsia. 1975 Jun;16(2):215-22. doi: 10.1111/j.1528-1157.1975.tb06050.x.
The effects of local brain temperature on acute focal penicillin epilepsy in the exposed hippocampus of cat were studied. Results from anesthetized and from immobilized, unanesthetized animals were compared. Over the temperature range 26 to 43 degrees C (at the alveus), the interictal spike interval and duration of the spike discharge varied inversely with temperature. The former showed a Q10 of 2.4 and the latter a Q10 of 1.5, with no difference due to type of preparation. A significant trans-hippocampal thermal gradient may imply that these values are underestimates by 20% or more. The low Q10 of duration of the paroxysmal discharge was consistent with the known temperature dependence of impulse conduction velocity of intracortical neural networks. The high Q10 of the interictal interval, on the other hand, was consistent with the view that some slow endogenous, perhaps metabolic factor such as a NA,K-ATPase modulated excitability at the focus of penicillin spikes.
研究了局部脑温对猫暴露海马中急性局灶性青霉素癫痫的影响。比较了麻醉动物和固定、未麻醉动物的结果。在26至43摄氏度（在齿状回）的温度范围内，发作间期棘波间隔和棘波放电持续时间与温度呈反比。前者的Q10为2.4，后者的Q10为1.5，不同制备类型之间无差异。显著的跨海马热梯度可能意味着这些值被低估了20%或更多。阵发性放电持续时间的低Q10与已知的皮质内神经网络冲动传导速度的温度依赖性一致。另一方面，发作间期间隔的高Q10与以下观点一致，即某些缓慢的内源性因素，可能是代谢因素，如钠钾ATP酶，调节了青霉素棘波灶的兴奋性。
