吡咯并吡啶取代噁唑烷酮类化合物的抗菌活性：各种C-5乙酰胺取代物的合成及体外构效关系
Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements.
作者信息
Paget Steven D, Boggs Christine M, Foleno Barbara D, Goldschmidt Raul M, Hlasta Dennis J, Weidner-Wells Michele A, Werblood Harvey M, Bush Karen, Macielag Mark J
机构信息
Johnson & Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA.
出版信息
Bioorg Med Chem Lett. 2006 Sep 1;16(17):4537-42. doi: 10.1016/j.bmcl.2006.06.023. Epub 2006 Jun 27.
PMID:16806921
Abstract
A series of pyrrolopyridine-substituted oxazolidinones containing various C-5 acetamide isosteres was synthesized and the structure-antibacterial activity relationships determined against a representative panel of susceptible and resistant Gram-positive bacteria.
摘要
合成了一系列含有各种C-5乙酰胺电子等排体的吡咯并吡啶取代噁唑烷酮，并测定了其对一组代表性的敏感和耐药革兰氏阳性菌的构效关系。
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