Paget Steven D, Boggs Christine M, Foleno Barbara D, Goldschmidt Raul M, Hlasta Dennis J, Weidner-Wells Michele A, Werblood Harvey M, Bush Karen, Macielag Mark J
Johnson & Johnson Pharmaceutical Research and Development, LLC, Raritan, NJ 08869, USA.
Bioorg Med Chem Lett. 2006 Sep 1;16(17):4537-42. doi: 10.1016/j.bmcl.2006.06.023. Epub 2006 Jun 27.
A series of pyrrolopyridine-substituted oxazolidinones containing various C-5 acetamide isosteres was synthesized and the structure-antibacterial activity relationships determined against a representative panel of susceptible and resistant Gram-positive bacteria.
合成了一系列含有各种C-5乙酰胺电子等排体的吡咯并吡啶取代噁唑烷酮,并测定了其对一组代表性的敏感和耐药革兰氏阳性菌的构效关系。