Royo Jose Luis, Moreno-Nogueira José Andrés, Galán Jose Jorge, González-Martín Antonio, Ruiz Agustin, González-Mancha Rosario, Real Luis Miguel
Breast Cancer Res Treat. 2006 Dec;100(3):331-3. doi: 10.1007/s10549-006-9258-0.
Nitric oxide (NO) plays a central role in the physiololgy and pathology of diverse tissues. Different studies provide data suggesting that the endothelial cell nitric oxide synthase (NOS3) expression in peritumoral microvessels might be a prognostic indicator in breast cancer patients. However, the putative contribution of common NOS3 germline variants to breast cancer risk remained unknown. A recent work comprising 269 breast cancer patients and 244 controls suggested that NOS3 Glu298Asp polymorphism is associated to breast cancer risk (OR=1.9). We performed an independent analysis of these results in 440 unrelated patients and 321 controls from Spanish population. Although our study was 90% powered to detect ORs >/=1.55, did not find any significant difference in the Glu298Asp allele distribution between cases and controls (P > 0.42). These putative reasons for this result are discussed.
一氧化氮（NO）在多种组织的生理学和病理学中起着核心作用。不同的研究提供的数据表明，肿瘤周围微血管中内皮细胞一氧化氮合酶（NOS3）的表达可能是乳腺癌患者的一个预后指标。然而，常见的NOS3种系变异对乳腺癌风险的假定影响仍然未知。最近一项针对269例乳腺癌患者和244例对照的研究表明，NOS3 Glu298Asp多态性与乳腺癌风险相关（比值比=1.9）。我们对来自西班牙人群的440例无亲属关系的患者和321例对照进行了这些结果的独立分析。尽管我们的研究有90%的把握检测到比值比≥1.55，但未发现病例组和对照组之间Glu298Asp等位基因分布有任何显著差异（P>0.42）。本文讨论了得出这一结果的可能原因。
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