Bui Chi, King Terri, Proffit William, Frazier-Bowers Sylvia
Department of Orthodontics, The University of North Carolina at Chapel Hill, 27599, USA.
Angle Orthod. 2006 Jul;76(4):564-9. doi: 10.1043/0003-3219(2006)076[0564:PCOCIP]2.0.CO;2.
The objective of this study is to characterize the convergences of dentofacial form of skeletal Class III malocclusion in individuals to test the fundamental hypothesis that there are distinct subtypes of Class III malocclusion.
A detailed phenotypic characterization was performed on a retrospective cohort of 309 subjects using cluster and principal component analyses on 67 cephalometric variables.
The results indicated that there are five clusters representing distinct subphenotypes. The principal component analysis suggested that the groupings of variables reflect anteroposterior and vertical dimensions rather than specific craniofacial structures. This may ultimately suggest that different genes are involved in controlling dimension vs structures.
Our phenotypic dissection of Class III malocclusion established distinct subtypes in a large sample of patients and will ultimately provide the basis for future familial studies to identify a causative gene.
本研究的目的是描述骨骼Ⅲ类错牙合患者牙颌面形态的汇聚情况，以检验Ⅲ类错牙合存在不同亚型这一基本假设。
对309名受试者的回顾性队列进行详细的表型特征分析，对67个头颅测量变量进行聚类和主成分分析。
结果表明有五个聚类代表不同的亚表型。主成分分析表明，变量分组反映的是前后和垂直维度，而非特定的颅面结构。这最终可能表明，不同基因参与控制维度与结构。
我们对Ⅲ类错牙合的表型剖析在大量患者样本中确定了不同的亚型，并将最终为未来的家族研究提供基础，以确定致病基因。
