二巯基丙磺酸钠（DMPS）和二巯基丁二酸（DMSA）在静脉内故意注射元素汞后，均不能有效地定量清除体内汞元素。

Neither DMPS nor DMSA is effective in quantitative elimination of elemental mercury after intentional IV injection.

作者信息

Eyer Florian, Felgenhauer Norbert, Pfab Rudolf, Drasch Gustav, Zilker Thomas

机构信息

Department of Toxicology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

出版信息

Clin Toxicol (Phila). 2006;44(4):395-7. doi: 10.1080/15563650600671795.

DOI:10.1080/15563650600671795

PMID:16809143

Abstract

BACKGROUND

Intravenous injection of elemental mercury (Hg) is rare and considered relatively harmless. Treatment recommendations vary and the effectiveness of chelation therapy is controversial.

CASE REPORT

A 27-year-old man intravenously injected 1.5 mL of elemental Hg. Within 12 hours he became febrile, tachycardic and dyspneic. Physical examination was unremarkable. X-rays showed scattered radiodense deposits in the lung, heart, intestinal wall, liver and kidney. The serum Hg level on admission was 172 microg/L and peaked on day 6 at 274 microg/L. Cumulative renal elimination during a five day oral treatment period with 2,3-dimercaptopropane-1-sulfonate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) was 8 mg and 3 mg, respectively.

CONCLUSION

Although urinary excretion could be enhanced during chelation therapy, Hg deposits in organs resulted in negligible elimination of mercury compared to the exposed dose.

摘要

背景

静脉注射元素汞（Hg）的情况罕见，且被认为相对无害。治疗建议各不相同，螯合疗法的有效性存在争议。

病例报告

一名27岁男性静脉注射了1.5毫升元素汞。12小时内，他出现发热、心动过速和呼吸困难。体格检查无异常。X线显示肺、心脏、肠壁、肝脏和肾脏有散在的高密度沉积物。入院时血清汞水平为172微克/升，第6天达到峰值274微克/升。在使用2,3-二巯基丙烷-1-磺酸钠（DMPS）和内消旋-2,3-二巯基琥珀酸（DMSA）进行为期五天的口服治疗期间，肾脏的累积排泄量分别为8毫克和3毫克。