儿童慢性单纯疱疹病毒性脑炎

Chronic herpes simplex virus encephalitis in childhood.

作者信息

Leen Wilhelmina G, Weemaes Corry M, Verbeek Marcel M, Willemsen Michèl A, Rotteveel Jan J

机构信息

Department of Pediatric Neurology, University Medical Centre St Radboud, Nijmegen, The Netherlands.

出版信息

Pediatr Neurol. 2006 Jul;35(1):57-61. doi: 10.1016/j.pediatrneurol.2005.12.015.

DOI:10.1016/j.pediatrneurol.2005.12.015

PMID:16814088

Abstract

Although herpes simplex virus is a major cause of acute encephalitis in childhood, chronic herpes simplex virus encephalitis has only rarely been reported. This report presents a case of chronic herpes simplex virus encephalitis in a 6-year-old female. Diagnosis was based on the detection of herpes simplex virus deoxyribonucleic acid by polymerase chain reaction in combination with the cerebrospinal fluid/serum ratio of herpes simplex virus-specific immunoglobulin G, the presence of herpes simplex virus-specific oligoclonal immunoglobulin G bands in cerebrospinal fluid, and calcifications in the temporal regions found on cerebral computed tomographic scan. Prolonged antiviral therapy was beneficial to later mental development.

摘要

尽管单纯疱疹病毒是儿童急性脑炎的主要病因，但慢性单纯疱疹病毒脑炎却鲜有报道。本报告介绍了一名6岁女性慢性单纯疱疹病毒脑炎的病例。诊断依据是通过聚合酶链反应检测单纯疱疹病毒脱氧核糖核酸，并结合单纯疱疹病毒特异性免疫球蛋白G的脑脊液/血清比值、脑脊液中单纯疱疹病毒特异性寡克隆免疫球蛋白G带的存在以及脑部计算机断层扫描发现的颞叶钙化。长期抗病毒治疗对后期智力发育有益。