具有前脉冲抑制缺陷的布拉德福德大鼠纹状体多巴胺-2受体上调。
Upregulation of striatal dopamine-2 receptors in Brattleboro rats with prepulse inhibition deficits.
作者信息
Shilling Paul D, Kinkead Becky, Murray Tiesha, Melendez Gilia, Nemeroff Charles B, Feifel David
机构信息
Department of Psychiatry, University of California, San Diego, California 92103-8218, USA.
出版信息
Biol Psychiatry. 2006 Dec 1;60(11):1278-81. doi: 10.1016/j.biopsych.2006.03.045. Epub 2006 Jun 30.
BACKGROUND
Brattleboro rats (BRATs) have natural deficits in prepulse inhibition (PPI) of the startle response similar to those exhibited by schizophrenia patients, which are reversed by antipsychotics. We sought to determine whether they also have increases in striatal dopamine-2 (D2) receptors found in some studies examining the brains of schizophrenia patients.
METHODS
Several days after startle testing, the brains of BRAT and Long Evans (LE) rats were removed, and D1 and D2 receptor levels were measured by autoradiography.
RESULTS
PPI was lower in BRATs consistent with previous reports. D2, but not D1, receptor binding was significantly higher in the nucleus accumbens shell and the dorsomedial caudate of BRAT compared with LE rats, consistent with some findings in schizophrenia patients. Furthermore, individual rat PPI was inversely correlated with D2 binding density.
CONCLUSIONS
These findings suggest that the dopamine system in BRATs is dysregulated and these abnormalities may contribute to the PPI deficits observed in these rats.
背景
布拉德福德大鼠（BRATs）在惊吓反应的前脉冲抑制（PPI）方面存在天然缺陷，类似于精神分裂症患者所表现出的缺陷，且抗精神病药物可逆转这些缺陷。我们试图确定它们纹状体多巴胺-2（D2）受体是否也像一些研究精神分裂症患者大脑时所发现的那样有所增加。
方法
在惊吓测试几天后，取出BRAT大鼠和长 Evans（LE）大鼠的大脑，通过放射自显影法测量D1和D2受体水平。
结果
与之前的报道一致，BRATs的PPI较低。与LE大鼠相比，BRAT大鼠伏隔核壳和背内侧尾状核中的D2受体结合显著更高，而D1受体结合无显著差异，这与精神分裂症患者的一些研究结果一致。此外，个体大鼠的PPI与D2结合密度呈负相关。
结论
这些发现表明BRATs的多巴胺系统失调，这些异常可能导致这些大鼠出现PPI缺陷。
Zotero 插件