Hardan Antonio Y, Muddasani Sri, Vemulapalli Madhuri, Keshavan Matcheri S, Minshew Nancy J
Stanford University, Department of Psychiatry and Behavioral Sciences, 401 Quarry Rd., Stanford, CA 94305, USA.
Am J Psychiatry. 2006 Jul;163(7):1290-2. doi: 10.1176/ajp.2006.163.7.1290.
The purpose of this study was to examine cortical thickness in autism in light of the postmortem evidence of cortical abnormalities of the disorder.
Magnetic resonance imaging (MRI) scans were acquired from 17 children with autism and 14 healthy comparison subjects, and sulcal and gyral thickness were measured for the total brain and for all lobes.
Increases in total cerebral sulcal and gyral thickness were observed in children with autism relative to comparison subjects. Similar findings were noted in the temporal and parietal lobes but not in the frontal and occipital lobes.
These preliminary findings indicate that increased cortical thickness may contribute to the increased gray matter volume and total brain size that have been observed in autism and may also be related to anomalies in cortical connectivity.
鉴于自闭症存在皮质异常的尸检证据,本研究旨在检测自闭症患者的皮质厚度。
对17名自闭症儿童和14名健康对照受试者进行磁共振成像(MRI)扫描,测量全脑及所有脑叶的脑沟和脑回厚度。
与对照受试者相比,自闭症儿童的全脑脑沟和脑回厚度增加。颞叶和顶叶也有类似发现,但额叶和枕叶未出现。
这些初步研究结果表明,皮质厚度增加可能导致自闭症患者脑灰质体积和全脑大小增加,也可能与皮质连接异常有关。