在现代药物研发中，将新型蛋白激酶抑制剂鉴定为靶点。
The identification of new protein kinase inhibitors as targets in modern drug discovery.
作者信息
Akritopoulou-Zanze Irini
机构信息
Abbott Laboratories, Department 4CP, Building AP10-1, 100 Abbott Park Road, Abbott Park, IL 60064-6099, USA.
出版信息
IDrugs. 2006 Jul;9(7):481-7.
PMID:16821161
Abstract
In recent years there has been great interest in developing protein kinase inhibitors as therapeutic agents for a variety of diseases. This article provides an overview on the history, development and validity of kinases as drug targets, as well as a description of kinase research, including its limitations, challenges and successes.
摘要
近年来，人们对开发蛋白激酶抑制剂作为多种疾病的治疗药物产生了浓厚兴趣。本文概述了激酶作为药物靶点的历史、发展和有效性，还描述了激酶研究，包括其局限性、挑战和成功之处。
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