Ahmadi Abbas, Mahmoudi Ali
Department of Science, School of Chemistry, Islamic Azad University, Karaj, Iran.
Arzneimittelforschung. 2006;56(5):346-50. doi: 10.1055/s-0031-1296732.
Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties were studied. Since a methoxy group has been added to the position 2 of the cyclohexane ring of PCP, the resulting compound is more polar than PCP. This compound was synthesized using an improved method with a higher yield. Its analgesic effect was studied using the tail-flick test on rats and was compared with that of ketamine (CAS 1867-66-9). The results showed that 2-methoxyphencyclidine increased tall-flick latencies as compared to the control group. The maximum analgesic effect of the compound occurred 5-10 min after its injection, while the effect of ketamine was observed 10-25 min after injection.
