小的可兴奋离子通道簇的动力学

The dynamics of small excitable ion channel clusters.

作者信息

Shuai J W, Jung P

机构信息

Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA.

出版信息

Chaos. 2006 Jun;16(2):026104. doi: 10.1063/1.2210827.

DOI:10.1063/1.2210827

PMID:16822036

Abstract

Through computational modeling we predict that small sodium ion channel clusters on small patches of membrane can encode electric signals most efficiently at certain magic cluster sizes. We show that this effect can be traced back to algebraic features of small integers and are universal for channels with a simple gating dynamics. We further explore physiologic conditions under which such effects can occur.

摘要

通过计算建模，我们预测细胞膜小斑块上的小钠离子通道簇在特定的神奇簇大小下能够最有效地编码电信号。我们表明，这种效应可以追溯到小整数的代数特征，并且对于具有简单门控动力学的通道来说是普遍存在的。我们进一步探索了可能出现这种效应的生理条件。