Herreno-Sáenz Diógenes, Xia Qingsu, Chiu Li-Ting, Fu Peter P
Department of Pharmacology and Toxicology, School of Medicine, University of Puerto Rico, P.O. Box 365067, San Juan, Puerto Rico 00936-5067.
Int J Environ Res Public Health. 2006 Jun;3(2):191-5. doi: 10.3390/ijerph2006030022.
Since the finding in the 1930s, a large number of polycyclic aromatic hydrocarbons (PAHs) of different structures have been tested for potential tumorigenicity. Structure-activity relationships of halo-PAHs have been investigated to determine the regions of a PAH that may be involved in cancer initiation. From these studies, a number of halo-PAHs were found to be tumorigenic in experimental animals. It was not until the 1980s that halo- PAHs were found to be present in the environment, including municipal incinerator fly ash, urban air, coal combustion, soil, snow, automobile exhausts, and tap water. Due to their widespread presence in the environment and their genotoxic activities, including carcinogenicity, many of these compounds may pose a health risk to humans. Although the biological activities, including metabolism, mutagenicity, and carcinogenicity, of halo- PAHs have been studied their phototoxicity and photo-induced biological activity have not been well examined. In this study, we study the photoirradiation of a series of structure-related halo-PAHs by UVA light in the presence of a lipid, methyl linoleate, and determine as to whether or not these compounds can induce lipid peroxidation. The halo-PAHs chosen for study include 2-bromonaphthalene, 1-chloroanthracene, 9,10- dibromoanthracene, 9-chlorophenanthrene, 9-bromophenanthrene, 7-chlorobenz[a]anthracene, 7- bromobenz[a]anthracene, 7-bromo-5-methylbenz[a]anthracene, 6-chlorobenzo[a]pyrene, and 6- bromobenzo[a]pyrene. The results indicate that upon photoirradiation by UVA all these compounds induced lipid peroxidation at different levels. These results suggest that halo-PAHs may be harmful to human health.
自20世纪30年代发现以来，大量不同结构的多环芳烃（PAHs）已被测试其潜在的致瘤性。卤代多环芳烃的构效关系已被研究，以确定多环芳烃中可能与癌症起始有关的区域。从这些研究中，发现许多卤代多环芳烃在实验动物中具有致瘤性。直到20世纪80年代，才发现卤代多环芳烃存在于环境中，包括城市垃圾焚烧飞灰、城市空气、煤炭燃烧、土壤、雪、汽车尾气和自来水中。由于它们在环境中的广泛存在及其遗传毒性活性，包括致癌性，这些化合物中的许多可能对人类健康构成风险。尽管卤代多环芳烃的生物活性，包括代谢、致突变性和致癌性已被研究，但其光毒性和光诱导生物活性尚未得到充分研究。在本研究中，我们研究了一系列结构相关的卤代多环芳烃在脂质亚油酸甲酯存在下的紫外光照射，并确定这些化合物是否能诱导脂质过氧化。选择用于研究的卤代多环芳烃包括2-溴萘、1-氯蒽、9,10-二溴蒽、9-氯菲、9-溴菲、7-氯苯并[a]蒽、7-溴苯并[a]蒽、7-溴-5-甲基苯并[a]蒽、6-氯苯并[a]芘和6-溴苯并[a]芘。结果表明，在紫外光照射下，所有这些化合物都在不同程度上诱导了脂质过氧化。这些结果表明卤代多环芳烃可能对人类健康有害。
