外泌体介导的RNA质量控制

RNA-quality control by the exosome.

作者信息

Houseley Jonathan, LaCava John, Tollervey David

机构信息

Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK.

出版信息

Nat Rev Mol Cell Biol. 2006 Jul;7(7):529-39. doi: 10.1038/nrm1964.

DOI:10.1038/nrm1964

PMID:16829983

Abstract

The exosome complex of 3'-->5' exonucleases is an important component of the RNA-processing machinery in eukaryotes. This complex functions in the accurate processing of nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the cytoplasm. However, it has been unclear how different classes of substrate are distinguished from one another. Recent studies now provide insights into the regulation and structure of the exosome, and they reveal striking similarities between the process of RNA degradation in bacteria and eukaryotes.

摘要

3'→5'核酸外切酶的外切体复合物是真核生物RNA加工机制的重要组成部分。该复合物在核RNA前体的精确加工以及细胞核和细胞质中RNA的降解过程中发挥作用。然而，目前尚不清楚不同类型的底物是如何相互区分的。最近的研究为外切体的调控和结构提供了见解，并且揭示了细菌和真核生物中RNA降解过程之间惊人的相似性。