Kumar Anil, Girdhar Anita, Girdhar B K
Clinical Division, Central Jalma Institute for Leprosy and Other Mycobacterial diseases, Taj Ganj, Agra.
Int J Lepr Other Mycobact Dis. 2005 Jun;73(2):115-21.
Leprosy prevalence has reportedly declined all over the world, but six countries, including India, are still endemic for the disease. India alone contributes about 60% to the world's leprosy case load, with the major share from its northern states. The present study done in Agra district was based on a randomly-selected sample of over 10% of the population, spread across 300 villages and 16 urban units of the district. A house-to-house survey was conducted from July 2001 to July 2003 in all the 26 selected panchayats (300 villages), all the 11 block headquarters which have an urban component, and 5 (out of 20) localities in Agra city. A population of 361,321 persons was examined for leprosy. A total of 592 leprosy cases [new and cases yet to complete a full course of multi-drug therapy (M.D.T.)] were found, giving a prevalence rate of 16.4/10,000 population. Although the overall prevalence was found to be similar in both rural and urban areas, there were pockets with high prevalence. More cases were detected in the eastern side of Agra (31.4/10,000 in Fatehabad and 28.5/10,000 in Bah Tahsils). Overall, the multibacillary (MB) leprosy rate was 22.3% and the child leprosy rate 8.4%. Of the 592 cases, 523 (88.3%) were new untreated cases, giving a new case detection rate of 14.5/10,000. The MB rate was 17% (89/523), and the child leprosy rate was 8.4% (44/523) among the new patients. The grade 2 deformity rate was found to be 4.8% (25/523) among these cases. The duration of disease among new cases was 32.3 months as compared to 48.1 months among prevalent (registered) cases (i.e., patients who had been diagnosed earlier and had yet to complete a full course of M.D.T.). The large number of undetected cases found in this survey suggests the need for continued intensive health education campaigns and case detection activities. This study highlights the fact that a large number of leprosy cases go undetected in the present integrated system which is mainly based on voluntary reporting of cases.
据报道,全球麻风病患病率已有所下降,但包括印度在内的六个国家仍是该病的流行地区。仅印度一国就占全球麻风病病例总数的约60%,其中大部分病例来自该国北部各邦。本研究在阿格拉地区开展,以该地区超过10%的人口为随机抽样对象,分布在300个村庄和16个城市区域。2001年7月至2003年7月,在所有选定的26个村委会(300个村庄)、所有具有城市组成部分的11个街区总部以及阿格拉市的5个(共20个)地区进行了逐户调查。对361321人进行了麻风病检查。共发现592例麻风病病例[新病例以及尚未完成全程多药疗法(M.D.T.)的病例],患病率为16.4/10000人口。尽管农村和城市地区的总体患病率相似,但仍有一些高患病率地区。在阿格拉东部发现了更多病例(法塔赫布尔为31.4/10000,巴赫县为28.5/10000)。总体而言,多菌型(MB)麻风病率为22.3%,儿童麻风病率为8.4%。在592例病例中,523例(88.3%)为新的未治疗病例,新病例发现率为14.5/10000。新患者中MB率为17%(89/523),儿童麻风病率为8.4%(44/523)。这些病例中的二级残疾率为4.8%(25/523)。新病例的患病时长为32.3个月,而现患(登记)病例(即早被诊断且尚未完成全程M.D.T.的患者)的患病时长为48.1个月。本次调查中发现大量未被检测出的病例,这表明需要持续开展强化健康教育活动和病例检测活动。本研究凸显了这样一个事实,即在目前主要基于病例自愿报告的综合系统中,大量麻风病病例未被检测出来。