猪模型中的超声心脏起搏
Ultrasonic cardiac pacing in the porcine model.
作者信息
Towe Bruce C, Rho Raymond
机构信息
Arizona State University, Bioengineering Department, Fulton College of Engineering, Tempe, AZ 85202-9709, USA.
出版信息
IEEE Trans Biomed Eng. 2006 Jul;53(7):1446-8. doi: 10.1109/TBME.2006.875715.
Periodic pulses of intense ultrasound energy at 70 kHz with 5-ms duration at 3 MPa SPL applied to the exposed pig myocardium at physiologic rhythms were observed to produce cardiac pacing. Ten animals were successfully paced at pulse width and energy conditions above a certain threshold. Sigmoid strength-duration curves characterizing ultrasound's effectiveness in pacing were observed to resemble those of electrical stimulation. We suggest that bioelectrical stimulatory effects of ultrasound on the heart are a radiation pressure effect and a manifestation of the known myocyte sensitivity to stretch.
在生理节律下，以3兆帕声压级、70千赫频率、5毫秒持续时间的高强度超声能量周期性脉冲施加于暴露的猪心肌，观察到可产生心脏起搏。在高于某一阈值的脉冲宽度和能量条件下，十只动物成功实现了起搏。观察到表征超声起搏有效性的S形强度-持续时间曲线类似于电刺激的曲线。我们认为，超声对心脏的生物电刺激作用是一种辐射压力效应，也是已知的心肌细胞对拉伸敏感性的一种表现。
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