童年期血清素功能增强可预防破坏性行为障碍男孩的青少年攻击行为。
Elevated childhood serotonergic function protects against adolescent aggression in disruptive boys.
作者信息
Halperin Jeffrey M, Kalmar Jessica H, Schulz Kurt P, Marks David J, Sharma Vanshdeep, Newcorn Jeffrey H
机构信息
Psychology Department, Queens College, 65-30 Kissena Boulevard, Flushing, NY 11367, USA.
出版信息
J Am Acad Child Adolesc Psychiatry. 2006 Jul;45(7):833-40. doi: 10.1097/01.chi.0000220855.79144.ae.
OBJECTIVE
This longitudinal study examined whether responsiveness of the neurotransmitter serotonin (5-HT) in childhood predicts adolescent aggression.
METHOD
Boys (N = 33) with disruptive behavior disorders who received assessments of central 5-HT function via the prolactin response to fenfluramine between 1990 and 1994 when they were 7 to 11 years old were re-evaluated clinically on average 6.7 years later.
RESULTS
After accounting for baseline aggression, early 5-HT function accounted for a significant proportion of variance in adolescent aggression. This prospective relationship of childhood 5-HT function with adolescent aggression (r = -0.71) and antisocial behavior (r = -0.59) was found primarily in adolescents who were aggressive during childhood. Irrespective of childhood aggression, no child with high 5-HT function was particularly aggressive at follow-up.
CONCLUSIONS
Low childhood 5-HT function appears important, but not sufficient, for the emergence of adolescent aggression. However, early high 5-HT function may protect against adolescent violence and aggression.
目的
这项纵向研究探讨了儿童期神经递质血清素（5-羟色胺，5-HT）的反应性是否能预测青少年的攻击性。
方法
对33名患有破坏性行为障碍的男孩进行研究，他们在1990年至1994年7至11岁时通过对芬氟拉明的催乳素反应接受了中枢5-HT功能评估，平均6.7年后进行了临床重新评估。
结果
在考虑基线攻击性之后，早期5-HT功能在青少年攻击性的变异中占很大比例。儿童期5-HT功能与青少年攻击性（r = -0.71）和反社会行为（r = -0.59）之间的这种前瞻性关系主要在儿童期有攻击性的青少年中发现。无论儿童期是否有攻击性，5-HT功能高的儿童在随访时都没有特别具有攻击性。
结论
儿童期低5-HT功能似乎对青少年攻击性的出现很重要，但并不充分。然而，早期高5-HT功能可能预防青少年暴力和攻击行为。
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