一种通过立体控制自由基方法从β-氨基醇制备受保护的季铵α-氨基酸的通用途径。
A general route to protected quaternary alpha-amino acids from beta-amino alcohols via a stereocontrolled radical approach.
作者信息
Wood Mark E, Penny Mark J, Steere Jenny S, Horton Peter N, Light Mark E, Hursthouse Michael B
机构信息
School of Biosciences (originally Department of Chemistry), University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter, UKEX4 4QD.
出版信息
Chem Commun (Camb). 2006 Jul 28(28):2983-5. doi: 10.1039/b604123j. Epub 2006 Jun 7.
DOI:10.1039/b604123j
PMID:16832511
Abstract
A radical-based approach facilitates the highly stereocontrolled functionalisation of beta-amino alcohols, opening up a new, generally applicable methodology for the preparation of quaternary alpha-amino acids.
摘要
基于自由基的方法有助于β-氨基醇的高度立体控制官能化，为制备季铵α-氨基酸开辟了一种新的、普遍适用的方法。
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