Zhu Yun-feng
Clinical Laboratory, Zhangjiagang Hospital of Chinese Traditional Medicine, Zhangjiagang, Jiangsu 215600, China.
Zhonghua Nan Ke Xue. 2006 Jun;12(6):540-1, 544.
To investigate the effect of castration on the quantity of androgen receptor (AR) and the epidermal growth factor (EGF) in the submaxillary salivary glands of castrated rats.
Sixty male Wistar rats, aged 30 to approximately 60 days, were randomly divided into three groups of 20 rats: castrated, sham-operated and normal control (unoperated). The submaxillary salivary glands of the castrated rats were removed one week after surgery, and so were those of the rats in the sham-operated and the normal control groups. The homogenized salivary gland was used for Western-blots.
The quantity of AR and EGF in the submaxillary salivary glands was decreased significantly in the castrated rats compared with that in the sham-operated and the normal control ( P < 0. 05). Moreover, EGF secreted by the submaxillary salivary glands was also decreased in the castrated rats (P < 0.05).
Castration affected the production of androgen receptor in the salivary gland, and also, could further affect the secretion of EGF from the salivary gland.
研究去势对去势大鼠颌下唾液腺雄激素受体（AR）数量及表皮生长因子（EGF）的影响。
将60只30至约60日龄的雄性Wistar大鼠随机分为三组，每组20只：去势组、假手术组和正常对照组（未手术）。去势组大鼠术后1周摘除颌下唾液腺，假手术组和正常对照组大鼠也同样摘除颌下唾液腺。将唾液腺匀浆用于蛋白质免疫印迹分析。
与假手术组和正常对照组相比，去势组大鼠颌下唾液腺中AR和EGF的数量显著减少（P < 0.05）。此外，去势组大鼠颌下唾液腺分泌的EGF也减少（P < 0.05）。
去势影响唾液腺中雄激素受体的产生，并且还可能进一步影响唾液腺中EGF的分泌。
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