用于双模态磁共振和荧光成像的基于树枝状大分子的纳米探针。
Dendrimer-based nanoprobe for dual modality magnetic resonance and fluorescence imaging.
作者信息
Talanov Vladimir S, Regino Celeste A S, Kobayashi Hisataka, Bernardo Marcelino, Choyke Peter L, Brechbiel Martin W
机构信息
Radiation Oncology Branch, Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1002, USA.
出版信息
Nano Lett. 2006 Jul;6(7):1459-63. doi: 10.1021/nl060765q.
A novel PAMAM dendrimer-based nanoprobe for dual magnetic resonance and fluorescence imaging modalities was synthesized. Fluorescence studies revealed that Gd(III) complexation to the probe has no effect on the quantum yield; however, increases in the dye content resulted in partial quenching. The potential of the new nanoprobe, G6-(Cy5.5)(1.25)(1B4M-Gd)(145), as a dual modality imaging agent was demonstrated in vivo by the efficient visualization of sentinel lymph nodes in mice by both MRI and fluorescence imaging modalities.
合成了一种基于聚酰胺-胺（PAMAM）树枝状大分子的新型纳米探针，用于双模态磁共振和荧光成像。荧光研究表明，Gd(III)与探针的络合对量子产率没有影响；然而，染料含量的增加导致了部分猝灭。新型纳米探针G6-(Cy5.5)(1.25)(1B4M-Gd)(145)作为双模态成像剂的潜力在体内得到了证明，通过磁共振成像（MRI）和荧光成像两种方式在小鼠体内有效地可视化了前哨淋巴结。
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