Ogura Osamu, Noguchi Tomohiro, Nagata Kohji, Noma Hidetoshi, Maemura Makoto, Higashimoto Masashi, Takebayashi Yuji, Maeda Shohzaburo
Dept. of Surgery, Ogura Memorial Hospital.
Gan To Kagaku Ryoho. 2006 Jul;33(7):1001-4.
A 71-year-old woman was seen at our hospital because of abdominal fullness and dyspnea. Examinations revealed a tumor in the pelvis with fluid collection and dissemination was seen in the abdomen and chest. Moreover, hyaluronate in ascites rose to 20,000 mg/dl. Finally, by cytology of ascites using immunohistochemistry, the patient was diagnosed as malignant peritoneal mesothelioma with disseminations in the abdomen and chest. After intraperitoneal administration of 25 mg of cisplatin (CDDP), we started carboplatin (CBDCA) plus paclitaxel (PTX) combination chemotherapy (each treatment course consisted of 100 mg of PTX and 400 mg of CBDCA on day 1 and PTX 100 mg on day 8 and day 15 by intravenous administration followed by 2 drug-free weeks). After the sixth course, a complete remission was observed. Malignant mesothelioma is known to have a poor prognosis. However, we successfully treated malignant peritoneal mesothelioma with CBDCA and PTX combined chemotherapy. Our case suggests that we could improve the prognosis of malignant mesothelioma by aggressive chemotherapy.
一名71岁女性因腹胀和呼吸困难前来我院就诊。检查发现盆腔有肿瘤，伴有腹腔和胸腔积液及播散。此外，腹水中透明质酸盐升至20,000mg/dl。最后，通过腹水免疫组化细胞学检查，患者被诊断为恶性腹膜间皮瘤伴腹腔和胸腔播散。腹腔注射25mg顺铂（CDDP）后，我们开始使用卡铂（CBDCA）加紫杉醇（PTX）联合化疗（每个疗程包括第1天静脉注射100mg PTX和400mg CBDCA，第8天和第15天静脉注射100mg PTX，随后休息2周）。第六个疗程后，观察到完全缓解。已知恶性间皮瘤预后较差。然而，我们成功地用CBDCA和PTX联合化疗治疗了恶性腹膜间皮瘤。我们的病例表明，积极的化疗可以改善恶性间皮瘤的预后。
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