双（恶唑啉基）吡啶-三氟甲磺酸铈（IV）配合物催化的α，β-不饱和2-酰基咪唑的对映选择性硝酮环加成反应
Enantioselective nitrone cycloadditions of alpha,beta-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine-cerium(IV) triflate complexes.
作者信息
Evans David A, Song Hyun-Ji, Fandrick Keith R
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
出版信息
Org Lett. 2006 Jul 20;8(15):3351-4. doi: 10.1021/ol061223i.
PMID:16836403
Abstract
[Structure: see text] Enantioselective nitrone cycloadditions with beta-substituted alpha,beta-unsaturated 2-acyl imidazoles catalyzed by bis(oxazolinyl)pyridine-cerium(IV) triflate complexes 1 have been reported. The isoxazolidine products were efficiently transformed into densely functionalized beta'-hydroxy-beta-amino acid derivatives.
摘要
[结构：见正文] 已报道了由双（恶唑啉基）吡啶-三氟甲磺酸铈（IV）配合物1催化的与β-取代的α，β-不饱和2-酰基咪唑的对映选择性硝酮环加成反应。异恶唑烷产物可有效地转化为功能密集的β'-羟基-β-氨基酸衍生物。
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