Hughes Martin
Intensive Care Medicine, Royal Infirmary, Glasgow G2 4AQ, UK.
Int J Antimicrob Agents. 2006 Aug;28(2):90-4. doi: 10.1016/j.ijantimicag.2006.05.021. Epub 2006 Jul 11.
This review will summarise the relevant pathophysiology of sepsis, the rationale for treatment with recombinant human activated protein C and the evidence for and against its use, and will provide evidence-based recommendations for its administration.