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α2-肾上腺素能受体阻断剂和促甲状腺激素释放激素(TRH)对家兔心血管系统的影响。

Effects of alpha 2-adrenoceptor blockade and thyrotropin-releasing hormone (TRH) on the cardiovascular system in the rabbit.

作者信息

Seligsohn E E, Koskinen L O

机构信息

Department of Physiology and Medical Biophysics, Uppsala University, Sweden.

出版信息

Acta Physiol Scand. 1991 Oct;143(2):187-94. doi: 10.1111/j.1748-1716.1991.tb09220.x.

Abstract

The effects of two different doses of thyrotropin-releasing hormone on regional blood flows were studied in urethane-anaesthetized rabbits pretreated with the alpha 2-adrenergic antagonists yohimbine and idazoxan. The effects of yohimbine were also studied using unanaesthetized rabbits. Blood flow measurements were performed using the tracer microsphere method. Thyrotropin-releasing hormone was injected i.v. at a dose of either 0.1 mg kg-1 or 2.0 mg kg-1. Yohimbine and idazoxan did not modify the effect of thyrotropin-releasing hormone on mean arterial blood pressure. In the anaesthetized animals, blockade of the alpha 2-adrenoceptors resulted in a vasoconstriction in several peripheral organs and the vasoconstriction increased after thyrotropin-releasing hormone administration. Pretreament with yohimbine reduced total cerebral blood flow moderately and in such animals thyrotropin-releasing hormone elicited only minor cerebral blood flow effects. Pretreatment with idazoxan did not reduce the total cerebral blood flow and in such animals it increased from 53 +/- 1 to 75 +/- 4 g min-1 100 g-1 (P less than 0.01) after the administration of the lower dose of thyrotropin-releasing hormone and from 64 +/- 5 to 112 +/- 17 g min-1 100 g-1 (P less than 0.01) after the higher dose. In the conscious animals, yohimbine caused an increase in mean arterial blood pressure and heart rate. Vascular resistance increased in several organs. The cerebral blood flow decreased in white matter (P less than 0.05) and the caudate nucleus (P less than 0.05). The results indicate that there is a yohimbine-sensitive mechanism involved in the cerebrovasodilating effect of thyrotropin-releasing hormone in anaesthetized rabbits.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

在预先用α2 - 肾上腺素能拮抗剂育亨宾和咪唑克生处理过的氨基甲酸乙酯麻醉的家兔中,研究了两种不同剂量的促甲状腺激素释放激素对局部血流的影响。还使用未麻醉的家兔研究了育亨宾的作用。采用示踪微球法进行血流测量。促甲状腺激素释放激素以0.1mg/kg或2.0mg/kg的剂量静脉注射。育亨宾和咪唑克生并未改变促甲状腺激素释放激素对平均动脉血压的作用。在麻醉动物中,α2 - 肾上腺素能受体的阻断导致几个外周器官血管收缩,且在给予促甲状腺激素释放激素后血管收缩增强。用育亨宾预处理适度降低了总脑血流量,在这类动物中促甲状腺激素释放激素仅引起轻微的脑血流效应。用咪唑克生预处理并未降低总脑血流量,在这类动物中,给予较低剂量的促甲状腺激素释放激素后,脑血流量从53±1增加到75±4g·min-1·100g-1(P<0.01),给予较高剂量后,从64±5增加到112±17g·min-1·100g-1(P<0.01)。在清醒动物中,育亨宾导致平均动脉血压和心率升高。几个器官的血管阻力增加。白质(P<0.05)和尾状核(P<0.05)的脑血流量减少。结果表明,在麻醉的家兔中,促甲状腺激素释放激素的脑血管舒张作用涉及一种对育亨宾敏感的机制。(摘要截短至250字)

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