CD44黏附分子在口腔癌中的作用。

The role of CD44 adhesion molecule in oral cavity cancer.

作者信息

Georgolios A, Batistatou A, Charalabopoulos A, Manolopoulos L, Charalabopoulos K

机构信息

Department of Physiology, Division of Adhesion Molecules, Ioannina University Medical School, Ioannina, Greece.

出版信息

Exp Oncol. 2006 Jun;28(2):94-8.

PMID:16837897

Abstract

CD44 is an adhesion molecule, member of the transmembrane glucoprotein family, with large number of isoforms identified in many human tissues, with particularly high expression in proliferating cells and squamous cell epithelium. This review is focused on the role of CD44 in the carcinogenesis of the oral cavity with special emphasis on its potential use for diagnosis and prognosis of cancer of oral cavity.

摘要

CD44是一种黏附分子，属于跨膜糖蛋白家族成员，在许多人体组织中可鉴定出大量异构体，在增殖细胞和鳞状上皮细胞中表达尤其高。本综述重点关注CD44在口腔癌发生中的作用，特别强调其在口腔癌诊断和预后方面的潜在用途。