一种使用HOF·CH₃CN形成喹喔啉N-氧化物和N,N'-二氧化物的新的高效途径。

A new efficient route for the formation of quinoxaline N-oxides and N,N'-dioxides using HOF.CH3CN.

作者信息

Carmeli Mira, Rozen Shlomo

机构信息

School of Chemistry, Tel-Aviv University, Tel-Aviv 69978, Israel.

出版信息

J Org Chem. 2006 Jul 21;71(15):5761-5. doi: 10.1021/jo0608016.

DOI:10.1021/jo0608016

PMID:16839160

Abstract

HOF.CH3CN, a very efficient oxygen-transfer agent made readily from fluorine and aqueous acetonitrile, was reacted with various quinoxaline derivatives to give the corresponding mono N-oxides and especially the N,N'-dioxides in very good yields under mild conditions and short reaction times.

摘要

HOF·CH₃CN是一种极易由氟与乙腈水溶液制得的高效氧转移剂，它与各种喹喔啉衍生物反应，能在温和条件及短反应时间下以很高的产率得到相应的单N-氧化物，尤其是N,N'-二氧化物。