Colorectal cancer: a model for epigenetic tumorigenesis.

作者信息

Wong J J L, Hawkins N J, Ward R L

机构信息

School of Medical Sciences, University of NSW, Sydney, New South Wales, Australia.

出版信息

Gut. 2007 Jan;56(1):140-8. doi: 10.1136/gut.2005.088799. Epub 2006 Jul 13.

DOI:10.1136/gut.2005.088799

PMID:16840508

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1856668/

Abstract

摘要

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Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band.

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Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.

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Hypermethylation of the MLH1 promoter with concomitant absence of transcript and protein occurs in small patches of crypt cells in unaffected mucosa from sporadic colorectal carcinoma.

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Colorectal cancer: a model for epigenetic tumorigenesis.

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Colorectal cancer: a model for epigenetic tumorigenesis.

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