(2R,3R)-和(2S,3S)-2-[(3-氯苯基)-(2-甲氧基苯氧基)甲基]吗啉的对映选择性合成
Enantioselective synthesis of (2R,3R)- and (2S,3S)-2- [(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine.
作者信息
Harding Wayne W, Hodge Matthis, Wang Zhixia, Woolverton William L, Parrish Damon, Deschamps Jeffrey R, Prisinzano Thomas E
出版信息
Tetrahedron Asymmetry. 2005 Jul 4;16(13):2249-2256. doi: 10.1016/j.tetasy.2005.06.012.
Abstract
The enantioselective synthesis of the (R,R)- and (S,S)-enantiomers of 1 from commercially available 3-chlorocinnamic acid is reported. The Sharpless asymmetric epoxidation was used to establish the stereocenters in the synthesis of both enantiomers of 1.
摘要
报道了从市售的3-氯肉桂酸对映选择性合成1的（R，R）-和（S，S）-对映体。在1的两种对映体的合成中，采用Sharpless不对称环氧化反应来构建立体中心。
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