Harding Wayne W, Hodge Matthis, Wang Zhixia, Woolverton William L, Parrish Damon, Deschamps Jeffrey R, Prisinzano Thomas E
Tetrahedron Asymmetry. 2005 Jul 4;16(13):2249-2256. doi: 10.1016/j.tetasy.2005.06.012.
The enantioselective synthesis of the (R,R)- and (S,S)-enantiomers of 1 from commercially available 3-chlorocinnamic acid is reported. The Sharpless asymmetric epoxidation was used to establish the stereocenters in the synthesis of both enantiomers of 1.
报道了从市售的3-氯肉桂酸对映选择性合成1的(R,R)-和(S,S)-对映体。在1的两种对映体的合成中,采用Sharpless不对称环氧化反应来构建立体中心。