Ernst Carrie L, Bird Suzanne A, Goldberg Joseph F, Ghaemi S Nassir
Department of Psychiatry, Massachusetts General Hospital, Boston, USA.
J Clin Psychiatry. 2006 May;67(5):720-6. doi: 10.4088/jcp.v67n0505.
Considerable debate exists about the value and wisdom of initiating "definitive" pharmacotherapies, particularly antidepressants, in the psychiatric emergency setting. We evaluated the nature and prevalence of medication prescriptions for patients discharged from an urban psychiatric emergency service and the extent to which pharmacotherapy initiation was predictive of follow-through with aftercare.
Records were reviewed for 675 consecutive individuals evaluated and discharged from a community-based psychiatric emergency service over a 3-month period (January 2003-March 2003). Information was obtained regarding diagnoses, past and current treatments, and demographic and clinical features, as well as outcomes for the subgroup of patients who received aftercare appointments within the institutional system.
Fifty-five percent of psychiatric emergency service visits resulted in discharge, with psychotropic drug prescriptions given to about 30% of this group. Prescriptions most often included antidepressants (64%), benzodiazepines (25%), nonbenzodiazepine sedatives (20%), anti-psychotics (18%), and mood stabilizers (10%). After controlling for potential confounders, the decision to prescribe was significantly associated with a clinical diagnosis of major depressive disorder or bipolar disorder and the preexisting use of psychotropic medications. Nonprescribing occurred most often in discharged patients who had suicidal ideation, substance abuse or dependence, and an existing outpatient psychiatrist. Follow-up emergency service and new outpatient appointments were more often given to patients discharged with a prescription, but follow-through with aftercare was not more likely in this group.
Psychiatrists in an emergency service prescribe antidepressants or other major psychotropics for about one third of discharged patients, rarely in the presence of suicidality or substance abuse or dependence, and with little evidence that initiating such medications in the emergency setting promotes more successful bridging to outpatient treatment.
对于在精神科急诊环境中启动“确定性”药物治疗,尤其是抗抑郁药的价值和合理性存在大量争议。我们评估了从城市精神科急诊服务出院患者的药物处方性质和流行情况,以及药物治疗启动对后续护理跟进的预测程度。
回顾了在3个月期间(2003年1月至2003年3月)从社区精神科急诊服务评估并出院的675名连续患者的记录。获取了有关诊断、既往和当前治疗、人口统计学和临床特征的信息,以及在机构系统内接受后续护理预约的患者亚组的结果。
55%的精神科急诊就诊导致出院,该组中约30%的患者开具了精神药物处方。处方最常包括抗抑郁药(64%)、苯二氮䓬类药物(25%)、非苯二氮䓬类镇静剂(20%)、抗精神病药(18%)和心境稳定剂(10%)。在控制潜在混杂因素后,开药决定与重度抑郁症或双相情感障碍的临床诊断以及既往使用精神药物显著相关。不开药最常发生在有自杀意念、药物滥用或依赖以及现有门诊精神科医生的出院患者中。随访急诊服务和新的门诊预约更常给予开具处方出院的患者,但该组后续护理的跟进可能性并不更高。
急诊服务中的精神科医生为约三分之一的出院患者开具抗抑郁药或其他主要精神药物,很少在存在自杀倾向、药物滥用或依赖的情况下开具,而且几乎没有证据表明在急诊环境中启动此类药物能促进更成功地过渡到门诊治疗。