Kakihara T, Fukuda T, Nemoto K, Ohnishi Y, Kusama K
Second Department of Pathology, Niigata University School of Medicine, Japan.
Acta Pathol Jpn. 1991 Aug;41(8):629-35. doi: 10.1111/j.1440-1827.1991.tb02532.x.
An unusual pancreatic tumor in a middle-aged man is reported. The tumor was a large encapsulated mass with necrosis and hemorrhage, and microscopically, it showed a predominant microcystic pattern with solid pattern areas. The clinical and histological features of this tumor were similar to those of solid and cystic tumor. Immunohistochemical studies showed that the tumor was positive for alpha 1-AT, NSE, CA 19-9 and somatostatin. Electron microscopy studies showed neurosecretory granules, intercellular junctions, annulate lamellae and aberrant crystalloid structures. These findings indicated that the tumor had differentiated into acinar, ductal and endocrine cells, suggesting that solid and cystic tumor originates from multipotential immature cells.
报告了一名中年男性的罕见胰腺肿瘤。该肿瘤为一个大的包膜肿块，伴有坏死和出血，显微镜下显示以微囊性为主，伴有实性区域。该肿瘤的临床和组织学特征与实性假乳头状瘤相似。免疫组化研究显示该肿瘤α1-抗胰蛋白酶、神经元特异性烯醇化酶、糖类抗原19-9和生长抑素呈阳性。电镜研究显示有神经分泌颗粒、细胞间连接、环状板层和异常晶体结构。这些发现表明该肿瘤已分化为腺泡、导管和内分泌细胞，提示实性假乳头状瘤起源于多能未成熟细胞。
