Zheng Zhe, Zhou You, Gao Hua-wei, Hu Sheng-shou
Department of Surgery, Cardiovascular Institute, Fu Wai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Jun;34(6):504-7.
To assess the prognostic accuracy for operative mortality of 4 different risk stratification models in Chinese patients underwent (coronary artery bypass graft) CABG.
Between 2002 and 2003, all patients undergoing CABG in our institution were prospectively scored for operative mortality using Parsonnet, EuroSCORE, Cleveland and OPR scoring systems and operative mortality was registered. Operative mortality is defined as postoperative death of any cause during hospitalization. Calibration was estimated using the Hosmer-Lemeshow goodness-of-fit test. Discrimination was evaluated using receiver operating characteristic (ROC) curves and area under a ROC curve (AUC).
Follow-up was able to be completed in 2251 prospectively scored patients. Registered operative mortality was 1.87% (42/2251). The overall expected mortality calculated by Parsonnet, EuroSCORE, Cleveland and OPR scoring systems were 5.78%, 2.82%, 3.30% and 1.65%, respectively. The actual operative mortality was within the range of 95% confidence interval of OPR model and the other 3 predicted significantly higher operative mortality. Among the four risk scores, Calibration was good in OPR model (chi(2) = 4.842, P = 20.182) and poor in other 3 models (P < 0.001) while discrimination was acceptable in Parsonnet, Cleveland and OPR scoring systems (AUC: 0.711, 0.754, 0.757, respectively) and excellent in EuroSCORE scoring system (0.813).
For Chinese patients undergoing CABG, OPR scoring system best predicted the operative mortality. All systems could be used to discriminate operative mortality for individual patient.
评估4种不同风险分层模型对接受冠状动脉旁路移植术(CABG)的中国患者手术死亡率的预测准确性。
2002年至2003年期间,对我院所有接受CABG的患者使用Parsonnet、欧洲心脏手术风险评估系统(EuroSCORE)、克利夫兰和OPR评分系统对手术死亡率进行前瞻性评分,并记录手术死亡率。手术死亡率定义为住院期间任何原因导致的术后死亡。使用Hosmer-Lemeshow拟合优度检验评估校准情况。使用受试者工作特征(ROC)曲线和ROC曲线下面积(AUC)评估辨别力。
对2251例前瞻性评分患者完成了随访。记录的手术死亡率为1.87%(42/2251)。Parsonnet、EuroSCORE、克利夫兰和OPR评分系统计算的总体预期死亡率分别为5.78%、2.82%、3.30%和1.65%。实际手术死亡率在OPR模型的95%置信区间范围内,其他3种模型预测的手术死亡率显著更高。在这四个风险评分中,OPR模型校准良好(χ² = 4.842,P = 20.182),其他3种模型校准较差(P < 0.001),而Parsonnet、克利夫兰和OPR评分系统的辨别力尚可(AUC分别为0.711、0.754、0.757),EuroSCORE评分系统辨别力出色(0.813)。
对于接受CABG的中国患者,OPR评分系统对手术死亡率的预测最佳。所有系统均可用于辨别个体患者的手术死亡率。