López Ramírez Ysabel, Vivenes Merlín, Miller Aixa, Pulido Aníbal, López Mora José, Arocha-Piñango Carmen Luisa, Marchi Rita
Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Científicas, Caracas, República Bolivariana de Venezuela.
Clin Chim Acta. 2006 Dec;374(1-2):69-74. doi: 10.1016/j.cca.2006.05.032. Epub 2006 May 26.
Recurrent miscarriage (RM) syndrome is not an uncommon obstetrical problem of multifactorial etiology. We investigated the role of the coagulation factor XIII (FXIII) Val34Leu polymorphism in RM.
We recruited 80 subjects (40 normal and 40 with history of RM; of each group 20 pregnant and 20 non-pregnant) and analyzed the prevalence of this polymorphism. The women recruited for the present study had similar age and did not have history of any hemostatic disorders. FXIII levels and activity and the rate of fibrin cross-linking by FXIII genotype Val34Val and Val34Leu were studied.
Genotype analyses of patients and normal revealed that the frequencies distribution of Val/Val and Val/leu were statistically similar (P<0.05): 62.5% and 60%, and 37.5% and 40%, respectively; no Leu/leu genotype was found. The FXIII-A subunit levels and activity were also found similar between Val/Val and Val/leu genotypes in the different groups, pregnant and non-pregnant, normal or with RM. The rate of FXIII alpha and gamma-chains fibrin cross-linking was not different between the 2 genotypes.
From our results we conclude that FXIII Val34Leu polymorphism does not appear to be associated to RM.
复发性流产（RM）综合征是一种病因多因素的常见产科问题。我们研究了凝血因子 XIII（FXIII）Val34Leu 多态性在 RM 中的作用。
我们招募了 80 名受试者（40 名正常人和 40 名有 RM 病史者；每组各 20 名孕妇和 20 名非孕妇），并分析了这种多态性的患病率。本研究招募的女性年龄相似，且无任何止血障碍病史。研究了 FXIII 水平、活性以及 FXIII 基因型 Val34Val 和 Val34Leu 的纤维蛋白交联率。
患者和正常人的基因型分析显示，Val/Val 和 Val/leu 的频率分布在统计学上相似（P<0.05）：分别为 62.5%和 60%，以及 37.5%和 40%；未发现 Leu/leu 基因型。在不同组（孕妇和非孕妇、正常或患有 RM）中，Val/Val 和 Val/leu 基因型之间的 FXIII-A 亚基水平和活性也相似。两种基因型之间的 FXIII α 和 γ 链纤维蛋白交联率没有差异。
根据我们的结果，我们得出结论，FXIII Val34Leu 多态性似乎与 RM 无关。
Zotero 插件