Deyneko Igor V, Bredohl Björn, Wesely Daniel, Kalybaeva Yulia M, Kel Alexander E, Blöcker Helmut, Kauer Gerhard
Department of Genome Analysis, GBF (German Research Centre for Biotechnology), D-38124 Braunschweig, Germany.
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W591-5. doi: 10.1093/nar/gkl337.
FeatureScan is a software package aiming to reveal novel types of DNA sequence similarity by comparing physico-chemical properties. Thirty-eight different parameters of DNA double strands such as charge, melting enthalpy, conformational parameters and the like are provided. As input FeatureScan requires two sequences, a pattern sequence and a target sequence, search conditions are set by selecting a specific DNA parameter and a threshold value. Search results are displayed in FASTA format and directly linked to external genome databases/browsers (ENSEMBL, NCBI, UCSC). An Internet version of FeatureScan is accessible at http://genome.gbf.de/featurescan/. As part of the HOBIT initiative (http://hobit.sourceforge.net/) FeatureScan is also accessible as a web service at its above home page. Currently, several preloaded genomes are provided at this Internet website (Homo sapiens, Mus musculus, Rattus norvegicus and four strains of Escherichia coli) as target sequences. Standalone executables of FeatureScan are available on request.
FeatureScan是一个软件包，旨在通过比较物理化学性质来揭示新型DNA序列相似性。它提供了38种不同的DNA双链参数，如电荷、熔解焓、构象参数等。FeatureScan需要两个序列作为输入，即模式序列和目标序列，通过选择特定的DNA参数和阈值来设置搜索条件。搜索结果以FASTA格式显示，并直接链接到外部基因组数据库/浏览器（ENSEMBL、NCBI、UCSC）。可通过http://genome.gbf.de/featurescan/访问FeatureScan的网络版。作为HOBIT计划（http://hobit.sourceforge.net/）的一部分，FeatureScan也可在其上述主页作为网络服务访问。目前，该互联网网站提供了几个预加载的基因组（智人、小家鼠、褐家鼠和四株大肠杆菌）作为目标序列。可根据要求提供FeatureScan的独立可执行文件。
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