Expresso：利用3D-Coffee将结构信息自动整合到多序列比对中。
Expresso: automatic incorporation of structural information in multiple sequence alignments using 3D-Coffee.
作者信息
Armougom Fabrice, Moretti Sébastien, Poirot Olivier, Audic Stéphane, Dumas Pierre, Schaeli Basile, Keduas Vladimir, Notredame Cedric
机构信息
Laboratoire Information Génomique et Structurale, CNRS UPR2589, Institute for Structural Biology and Microbiology (IBSM), Parc Scientifique de Luminy, 163 Avenue de Luminy, FR- 13288, Marseille cedex 09, France.
出版信息
Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W604-8. doi: 10.1093/nar/gkl092.
Expresso is a multiple sequence alignment server that aligns sequences using structural information. The user only needs to provide sequences. The server runs BLAST to identify close homologues of the sequences within the PDB database. These PDB structures are used as templates to guide the alignment of the original sequences using structure-based sequence alignment methods like SAP or Fugue. The final result is a multiple sequence alignment of the original sequences based on the structural information of the templates. An advanced mode makes it possible to either upload private structures or specify which PDB templates should be used to model each sequence. Providing the suitable structural information is available, Expresso delivers sequence alignments with accuracy comparable with structure-based alignments. The server is available on http://www.tcoffee.org/.
Expresso是一个多序列比对服务器，它利用结构信息来比对序列。用户只需提供序列。该服务器运行BLAST以识别PDB数据库中序列的紧密同源物。这些PDB结构被用作模板，以使用诸如SAP或Fugue等基于结构的序列比对方法来指导原始序列的比对。最终结果是基于模板的结构信息对原始序列进行的多序列比对。高级模式使得上传私有结构或指定应使用哪些PDB模板来对每个序列进行建模成为可能。如果有合适的结构信息，Expresso提供的序列比对准确性可与基于结构的比对相媲美。该服务器可在http://www.tcoffee.org/上获取。
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