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糖皮质激素性骨质疏松症的预防趋势

Trends in prevention of glucocorticoid-induced osteoporosis.

作者信息

Saag Kenneth G, Gehlbach Stephen H, Curtis Jeffrey R, Youket Thomas E, Worley Karen, Lange Jeffrey L

机构信息

UAB Center for Education and Research on Musculoskeletal Disorders, University of Alabama at Birmingham, 35294, USA.

出版信息

J Rheumatol. 2006 Aug;33(8):1651-7.

Abstract

OBJECTIVE

To determine longitudinal patterns and predictors for the utilization of bone mass measurements and anti-osteoporotic medications in the prevention of glucocorticoid-induced osteoporosis.

METHODS

Within a managed care population of 7 million persons, we identified 3,125 adult men and women who had initiated longterm glucocorticoid therapy (>or=7.5 mg/day of prednisone equivalent for > 6 mo). The study population was examined by 3 biennial intervals between years 1996 and 2001 for receipt of a bone mass measurement and use of anti-osteoporotic medication (bisphosphonate, calcitonin, raloxifene, hormone replacement therapy).

RESULTS

Receipt of a bone mass measurement increased among postmenopausal women from 10% in 1996-97 to 19% in 2000-01, but remained below 6% in all biennial intervals among women under age 50 and men. The use of anti-osteoporotic medication was most common among postmenopausal women, where it approached 50%. The largest absolute increase in anti-osteoporotic medication utilization was among women ages 65 and over, increasing from 24% in 1996-97 to 44% in 2000-01. The specialty of physician providing care was associated with receipt of both testing and treatment. Odds of receipt of a bone mass measurement and anti-osteoporotic medication were 3 to 4 times greater among patients of rheumatologists compared to those of internists or family practitioners.

CONCLUSION

Among patients initiating longterm glucocorticoid therapy, the proportion of individuals receiving a bone mass measurement or anti-osteoporotic medication remains relatively low, but has improved temporally among postmenopausal women.

摘要

目的

确定骨量测量及抗骨质疏松药物在预防糖皮质激素诱发的骨质疏松症中的纵向模式及预测因素。

方法

在一个700万人口的管理式医疗人群中,我们识别出3125名开始长期糖皮质激素治疗(相当于泼尼松剂量≥7.5毫克/天,持续超过6个月)的成年男性和女性。在1996年至2001年期间,对研究人群进行了3次两年期检查,以了解其骨量测量情况及抗骨质疏松药物(双膦酸盐、降钙素、雷洛昔芬、激素替代疗法)的使用情况。

结果

绝经后女性接受骨量测量的比例从1996 - 1997年的10%增至200-2001年的19%,但在50岁以下女性和男性的所有两年期检查中,该比例均低于6%。抗骨质疏松药物的使用在绝经后女性中最为常见,接近50%。65岁及以上女性抗骨质疏松药物使用的绝对增幅最大,从1996 - 1997年的24%增至2000 - 2001年的44%。提供治疗的医生专业与检查及治疗的接受情况相关。与内科医生或家庭医生的患者相比,风湿病医生的患者接受骨量测量及抗骨质疏松药物的几率高出3至4倍。

结论

在开始长期糖皮质激素治疗的患者中,接受骨量测量或抗骨质疏松药物的个体比例仍然相对较低,但绝经后女性在这方面随时间有所改善。

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