• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

老年人中抗焦虑药和催眠药的临床药代动力学。治疗考量（第二部分）

Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).

作者信息

Greenblatt D J, Harmatz J S, Shader R I

机构信息

Department of Psychiatry, Tufts University School of Medicine, Boston, Massachusetts.

出版信息

Clin Pharmacokinet. 1991 Oct;21(4):262-73. doi: 10.2165/00003088-199121040-00003.

DOI:10.2165/00003088-199121040-00003
PMID:1684744
Abstract

Part I of this article, which appeared in the previous issue of the Journal, discussed the scope of and scientific basis for special pharmacokinetic studies of anxiolytic and hypnotic drugs in the elderly, and examined the methodology and results of such studies and the prediction of pharmacokinetic changes. In Part II the authors continue their review, focusing on age-related pharmacodynamic changes in the effects of these drugs, the attempts to correlate pharmacokinetic with pharmacodynamic findings, and the clinical applications of these data.

摘要

本文的第一部分发表于上一期《期刊》，讨论了老年人抗焦虑和催眠药物特殊药代动力学研究的范围和科学依据，审视了此类研究的方法和结果以及药代动力学变化的预测。在第二部分中，作者继续进行综述，重点关注这些药物作用中与年龄相关的药效学变化、将药代动力学与药效学研究结果相关联的尝试以及这些数据的临床应用。

相似文献

1
Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).老年人中抗焦虑药和催眠药的临床药代动力学。治疗考量（第二部分）
Clin Pharmacokinet. 1991 Oct;21(4):262-73. doi: 10.2165/00003088-199121040-00003.
2
Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part I).老年人抗焦虑药和催眠药的临床药代动力学。治疗考量（第一部分）
Clin Pharmacokinet. 1991 Sep;21(3):165-77. doi: 10.2165/00003088-199121030-00002.
3
Enhancement of GABAergic activity: neuropharmacological effects of benzodiazepines and therapeutic use in anesthesiology.增强 GABA 能活性：苯二氮䓬类药物的神经药理学作用及其在麻醉学中的治疗用途。
Pharmacol Rev. 2011 Mar;63(1):243-67. doi: 10.1124/pr.110.002717. Epub 2011 Jan 18.
4
Psychoactive drugs in the elderly: antipsychotics and anxiolytics.老年人使用的精神活性药物：抗精神病药和抗焦虑药。
Geriatrics. 1988 Sep;43(9):53-7, 61-2, 65.
5
[Excessive prescribing of hypnotic and anxiolytic drugs in Japan].
Nihon Rinsho. 2015 Jun;73(6):1049-56.
6
Trends in anxiolytic-hypnotic use and polypharmacy in Taiwan, 2002-2009: a nationwide, population-based survey.2002 - 2009年台湾地区抗焦虑催眠药使用及联合用药趋势：一项基于全国人口的调查
Psychiatr Serv. 2014 Feb 1;65(2):208-14. doi: 10.1176/appi.ps.201300066.
7
[Update on benzodiazepines].
Recenti Prog Med. 1992 May;83(5):249-54.
8
The use of benzodiazepines in the aged patient: clinical and pharmacological considerations.老年患者使用苯二氮䓬类药物：临床及药理学考量
Pak J Pharm Sci. 2008 Apr;21(2):144-50.
9
Guidelines for the clinical use of benzodiazepines: pharmacokinetics, dependency, rebound and withdrawal. Canadian Society for Clinical Pharmacology.苯二氮䓬类药物临床应用指南：药代动力学、依赖性、反跳及戒断反应。加拿大临床药理学协会。
Can J Clin Pharmacol. 1999 Summer;6(2):69-83.
10
[The mechanism of action of benzodiazepine and its consequences for therapy].
Clin Ter. 1992 Apr;140(4):331-43.

引用本文的文献

1
Incidence of and Characteristics Associated With Long-term Benzodiazepine Use in Finland.芬兰苯二氮䓬类药物长期使用的发生率及特点。
JAMA Netw Open. 2020 Oct 1;3(10):e2019029. doi: 10.1001/jamanetworkopen.2020.19029.
2
Population Pharmacokinetics of Fentanyl in the Critically Ill.芬太尼在危重症患者中的群体药代动力学
Crit Care Med. 2016 Jan;44(1):64-72. doi: 10.1097/CCM.0000000000001347.
3
Evaluation and optimisation of current milrinone prescribing for the treatment and prevention of low cardiac output syndrome in paediatric patients after open heart surgery using a physiology-based pharmacokinetic drug-disease model.

本文引用的文献

1
Oxazepam kinetics: effects of age and sex.奥沙西泮动力学：年龄和性别的影响。
J Pharmacol Exp Ther. 1980 Oct;215(1):86-91.
2
The effect of age on the pharmacokinetics of diazepam.年龄对地西泮药代动力学的影响。
Clin Sci (Lond). 1980 Dec;59(6):479-83. doi: 10.1042/cs0590479.
3
Diazepam disposition determinants.地西泮处置的决定因素。
运用基于生理学的药代动力学药物-疾病模型评价和优化米力农在小儿心脏直视手术后治疗和预防低心排血量综合征中的应用。
Clin Pharmacokinet. 2014 Jan;53(1):51-72. doi: 10.1007/s40262-013-0096-z.
4
Cognitive toxicity of drugs used in the elderly.老年人使用药物的认知毒性。
Dialogues Clin Neurosci. 2001 Sep;3(3):181-90. doi: 10.31887/DCNS.2001.3.3/llvonmoltke.
5
Psychotropic drug use among older people in general practice: discrepancies between opinion and practice.老年人在全科医疗中的精神药物使用：观念与实践之间的差异。
Br J Gen Pract. 2010 Apr;60(573):e156-62. doi: 10.3399/bjgp10X483922.
6
Indiplon in the treatment of sleep disorders.吲达帕胺治疗睡眠障碍。
Neuropsychiatr Dis Treat. 2007 Dec;3(6):765-73. doi: 10.2147/ndt.s494.
7
Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10.衰老对人肝微粒体中丙戊酸葡萄糖醛酸化的影响以及尿苷二磷酸葡萄糖醛酸基转移酶UGT1A4、UGT1A8和UGT1A10的作用。
Drug Metab Dispos. 2009 Jan;37(1):229-36. doi: 10.1124/dmd.108.022426. Epub 2008 Oct 6.
8
A double-blind, placebo-controlled investigation of the residual psychomotor and cognitive effects of zolpidem-MR in healthy elderly volunteers.一项关于唑吡坦缓释片对健康老年志愿者残留精神运动和认知影响的双盲、安慰剂对照研究。
Br J Clin Pharmacol. 2006 Nov;62(5):538-45. doi: 10.1111/j.1365-2125.2006.02705.x.
9
The influence of cardiovascular physiology on dose/pharmacokinetic and pharmacokinetic/pharmacodynamic relationships.心血管生理学对剂量/药代动力学及药代动力学/药效学关系的影响。
Clin Pharmacokinet. 2006;45(5):433-48. doi: 10.2165/00003088-200645050-00001.
10
Drug dosage in the elderly: dermatological drugs.老年人的药物剂量：皮肤科药物
Drugs Aging. 2006;23(3):203-15. doi: 10.2165/00002512-200623030-00003.
Clin Pharmacol Ther. 1980 Mar;27(3):301-12. doi: 10.1038/clpt.1980.40.
4
Diazepam kinetics in relation to age and sex.地西泮动力学与年龄和性别的关系。
Pharmacology. 1981;23(1):24-30. doi: 10.1159/000137524.
5
Renal disease, age, and oxazepam kinetics.肾脏疾病、年龄与奥沙西泮的药代动力学
Clin Pharmacol Ther. 1981 Dec;30(6):805-9. doi: 10.1038/clpt.1981.241.
6
GABA stimulation of 3H-diazepam binding in aged mice.γ-氨基丁酸对老年小鼠中3H-地西泮结合的刺激作用。
Life Sci. 1981 Aug 31;29(9):971-4. doi: 10.1016/0024-3205(81)90400-8.
7
Kinetics and clinical effects of flurazepam in young and elderly noninsomniacs.氟西泮在年轻和老年非失眠者中的动力学及临床效应
Clin Pharmacol Ther. 1981 Oct;30(4):475-86. doi: 10.1038/clpt.1981.191.
8
Disposition of oxazepam in relation to age, sex, and cigarette smoking.
Klin Wochenschr. 1981 Aug 17;59(16):899-903. doi: 10.1007/BF01721923.
9
Antipyrine kinetics in the elderly: prediction of age-related changes in benzodiazepine oxidizing capacity.老年人中安替比林动力学：苯二氮䓬氧化能力与年龄相关变化的预测
J Pharmacol Exp Ther. 1982 Jan;220(1):120-6.
10
Drug therapy: drug disposition in old age.药物治疗：老年人的药物处置
N Engl J Med. 1982 May 6;306(18):1081-8. doi: 10.1056/NEJM198205063061804.